IVF Success Rates Over 40 with Own Eggs and Donor Eggs

For many, the possibility of getting pregnant after a certain age seems unattainable. However, pregnancy after 40 is possible for some women, whether naturally or assisted with a treatment like IVF. The IVF success rates over 40 do drop pretty significantly, but success shouldn’t be ruled out entirely.

IVF Success Rates Over 40 with Own Eggs

Women 40 and over encounter lower success rates in regards to all fertility treatments, including IVF. In short, IVF success rates over 40 with own eggs significantly different from success rates under 40. However, certain factors change the success rates. Here are best IVF clinics-top 20 success rates over 40 with own eggs sorted by live births, age 41-42 from the CDC 2015.

ClinicCityUnder 4141-4243-44>44
Reproductive Medicine Associates of New JerseyBASKING RIDGE, NJ63.0%45.0%2/5
HRC Fertility-PasadenaPASADENA, CA38.4%33.3%1/151/4
Long Island IVFMELVILLE, NY33.4%25.5%0.00/3
Institute for Reproductive HealthCINCINNATI, OH35.2%25.0%1/7
Institute for Reproductive Medicine and ScienceLIVINGSTON, NJ36.2%24.5%1/140/3
South Florida Institute for Reproductive MedicineSOUTH MIAMI, FL49.2%23.8%0/80/4
The A.R.T. Institute of WashingtonBETHESDA, MD38.5%23.3%
Palo Alto Medical Foundation Fertility PhysiciansSAN JOSE, CA30.6%22.0%5.0%0/9
Reproductive Medicine Associates of New YorkNEW YORK, NY42.9%21.5%0.00/8
NYU Fertility CenterNEW YORK, NY29.1%20.8%9.5%
Fertility Solutions, PCDEDHAM, MA34.9%17.9%1/17
Shady Grove Fertility RSC-TowsonTOWSON, MD41.5%17.7%2/170/3
HRC Fertility-EncinoENCINO, CA50.0%17.2%3/132/8
Columbia University Center for Women’s Reproductive CareNEW YORK, NY23.2%17.1%2/180/6
IVF New EnglandLEXINGTON, MA32.7%16.7%10.70/1
Weill Medical College of Cornell UniversityNEW YORK, NY36.0%16.5%6.7%1.6%
Fertility and Reproductive Medicine Center at Washington University SchoolST. LOUIS, MO49.1%16.0%0/3
Stanford Medicine Fertility & Reproductive HealthPALO ALTO, CA30.4%16.0%0/170/8
Shady Grove Fertility Reproductive Science CenterROCKVILLE, MD36.4%15.6%6.5%5.0%
Main Line Fertility and Reproductive MedicineBRYN MAWR, PA32.5%15.6%17.4%0/3

Over the age of 40, birth rates with own eggs steadily and rapidly decline, on average. To put things in perspective, the own eggs live birth rate for patients age 40 was 16%. At age 43, the own eggs live birth rate dropped to 5%. Over 44, the own eggs live birth rate dropped further still, to 1%. At the same time, some best IVF clinics for over 40 have much higher rates than these; they are specialty clinics with specific programs for this age group.

What makes IVF success rates over 40 with own eggs lower than average?

Many people ask questions related to why IVF success rates over 40 with own eggs are lower than the success rates for younger women. To answer them, we have to consider what makes IVF successful in the first place.

IVF success depends on fairly good numbers of healthy, viable eggs. In other words, both egg quality and egg quantity matter. As women age over 40, both of those factors get impacted. Fewer eggs develop, and of them, fewer eggs are of excellent quality.

According to some experts, one of the primary ways age impacts egg quality relates to chromosomes. Eggs with an abnormal number of chromosomes lead to failed IVF transfer. As women age, the potential for an abnormality in chromosomes increases very steadily.

Thus, due to the likelihood of a lack of viable eggs, IVF success rates over 40 with own eggs drop and continue to decline the older a woman gets.

IVF Success Rates Over 40 with Donor Eggs

While all of the above information is true regarding non-donor eggs over 40, it isn’t true when it comes to donor eggs. Let’s compare best IVF clinics-top 20 success rates over 40 with donor eggs sorted by live births, age 41-42 from the CDC 2015.

ClinicCityUnder 4141-4243-44>44
Southern California Reproductive CenterBEVERLY HILLS, CA57.8%61.9%2/30/2
Oregon Reproductive MedicinePORTLAND, OR64.7%60.6%4/61/2
Southern California Center for Reproductive MedicineNEWPORT BEACH, CA64.4%58.6%6/11
Colorado Center for Reproductive MedicineLONE TREE, CO63.0%55.6%51.5%5/17
Houston Fertility SpecialistsHOUSTON, TX48.2%54.3%3/111/3
Fertility and Surgical Associates of CaliforniaTHOUSAND OAKS, CA53.1%53.7%5/91/3
Reproductive Medicine Associates of New JerseyBASKING RIDGE, NJ54.9%52.7%49.1%5/13
NYU Fertility CenterNEW YORK, NY48.1%50.7%37.0%7/13
University of Pennsylvania, Penn Fertility CarePHILADELPHIA, PA39.4%50.0%3/130/1
South Florida Institute for Reproductive MedicineSOUTH MIAMI, FL49.2%50.0%2/160/2
Reproductive Science Center of the San Francisco Bay AreaSAN RAMON, CA51.2%47.1%11/190/1
Kaiser Permanente Center for Reproductive HealthFREMONT, CA46.8%46.2%5/110/3
Pacific Fertility CenterSAN FRANCISCO, CA46.5%45.9%11/192/5
Reproductive Medicine Associates of ConnecticutNORWALK, CT49.1%43.3%2/101/1
Zouves Fertility CenterFOSTER CITY, CA41.1%42.9%2/80/2
HRC Fertility-EncinoENCINO, CA54.4%42.4%3/1340.7
California Fertility PartnersLOS ANGELES, CA40.5%41.4%3/162/7
Dominion Fertility and EndocrinologyARLINGTON, VA42.5%40.9%2/131/1
HRC Fertility-PasadenaPASADENA, CA47.4%40.9%7/1655.0
Center for Reproductive Medicine, PAORLANDO, FL39.6%40.6%3/80/2

Women over 40 who use IVF to become pregnant stand a very good chance of success if they use donor eggs. The live birth rates for women using donor eggs vary only slightly between the ages of 30 and 47. This means that when women over 40 use donor eggs, their chances of success remain largely the same, barring other factors.

A woman in her 30s using donor eggs has almost the same likelihood of IVF success as a woman in her 40s who uses donor eggs.

This information shows even more clearly that the cause of the decline in IVF success rates over 40 is almost solely to do with eggs. A woman’s ability to carry and deliver a baby over 40 isn’t much different than a younger woman’s ability. The difference has to do with egg quality and quantity. That’s why fertility specialists recommend using donor eggs when a woman is age 40 or older.

Experts believe that while the age of the eggs matter, the age of the uterus doesn’t. At least, it has very little to do with IVF success rates over 40.

When choosing a donor for eggs, women over 40 should choose a woman that is younger and with few health issues. IVF success over 40 depends so much on healthy, viable eggs, that whoever you choose to donate eggs for the procedure should be in optimal health and age.

How to Increase IVF Success Rates Over 40

Some IVF clinics specialize in IVF after 40 and provide women with tips and information to increase the IVF success rate over 40. They say that are a number of things women and their doctors can do to increase the chance of success.

Choose Donor Eggs

To significantly increase IVF success rates over 40, consider using donor eggs. As previously described, donor eggs from healthy, younger women generally lead to better success. If you remain open to the possibility, your chances of success go up.

Donor eggs increase the chances of success by upwards of 70 percent in some cases. The difficulty in choosing egg donation lies in the emotional attachment many people have to the dream of a biological child. Choosing donor eggs can be difficult for many people. For those who’ve struggled for many years to conceive, it is sometimes the only option.

If a woman is over 42, the likelihood of pregnancy with own eggs sharply declines. Also, note that many IVF clinics limit the age for treatment to 45, after which a patient must choose donor eggs. This is because the chance of success using a woman’s own eggs after 45 is 1% or less.

Consider Mini IVF Procedures

Some patients over 40 choose Mini-IVF, a procedure which requires a smaller amount of fertility medication and aims to produce one to three viable, healthy eggs. Some experts believe Mini-IVF improves IVF success rates over 40 because mini-IVF results in better-quality eggs and embryos. Regardless, the reduced cost of the treatment can be beneficial.

Supplement with DHEA

Though it is not talked about often, DHEA supplementation provides several potential benefits that increase chances of success over 40. Benefits include better and more eggs, higher rates of natural pregnancy, fewer miscarriages, more successful IVF cycles, and a smaller chance of chromosomal abnormality.

Some IVF clinics for over 40 suggest that DHEA supplementation could potentially eliminate the need to use donor eggs for some women.

Opt for Earlier Egg Retrieval

Retrieving eggs earlier in women over 40 improves the chances of positive outcomes and IVF success rate. Some IVF clinics for over 40 state that, sometimes, eggs in women over 40 mature too quickly. As a result, by the time fertility specialists retrieve the eggs, they are not viable or healthy because they have matured too much. So, the clinic suggests that doctors working with women over 40 closely monitor the ovarian cycle in order to better control the timing.

Make Lifestyle Changes

Some fertility specialists suggest that making appropriate lifestyle choices improves IVF success over 40. Changes in diet, smoking habits, and weight loss can have an impact. Cutting smoking, for example, dramatically improves odds of success. Women over 40 who smoke require twice the number of IVF treatments. Additionally, smokers need to take more fertility drugs than non-smokers and experience more failed implantation cycles.

Suggested lifestyle habit changes include:

  • Quit smoking at least 3 months before fertility treatment
  • Lose weight, if you are overweight (may increase chances of success)
  • Exercise regularly
  • If you’re underweight, seek help getting to a normal weight range
  • Take supplements
  • Cut excess sugar or unhealthy food out of your diet

Choose a Specialty IVF Clinic for Over 40

Successful IVF over 40 involves choosing a clinic that specializes in pregnancy after 40. These best IVF clinics for over 40 typically have much higher success rates. In all likelihood, the clinic’s team does a good job of screening patients before making IVF attempts. The team probably spends a great deal of time determining which fertility diagnoses have the best possible IVF success rate over 40.

Clinics with older pregnancy specialties are also likely more equipped, and knowledgeable about treatments specific to that age group.

Some clinics for over 40 have an IVF success rate over 40 of 60% or higher. If a clinic’s success rate in the over 40 demographic is very low, keep searching for a clinic with better outcomes. Many reputable clinics publish this information online. If not, you can research it in the IVF success rates table.

Some clinics specialize in IVF treatments in older women, because the procedures and practices require special attention. Fertility specialists may also recommend certain IVF treatments with higher chances of success in older patients.

Get Help Sooner

Women over 40 who are experiencing fertility challenges need to seek help as soon as possible. Age does matter when it comes to pregnancy. Even if a couple is unsure about whether or not IVF is right for them, sooner is better than later in these cases.

Experts suggest that after IVF three or four months with no successful pregnancy, you should get a consultation or consider fertility testing. This includes hormone testing for egg equality and potential early menopause.

Set up a consultation with a high success rate IVF clinic in your area that specializes in pregnancy over 40.