Comments on IVF Authority: DQ-alpha Matching in IVF: The Controversy, How It ...

Were you and your husband tested for both DQa and ...

2010-07-20T16:18:11.645-07:00

Were you and your husband tested for both DQa and HLA similarities. If so what where were the tests done ande what were the exact results?

Since no one is born with NK activation...it is possible that you developed NKa activity over time.

Geoff Sher

My husband and I got pregnant in March 2006 on the...

2010-07-13T20:54:43.507-07:00

My husband and I got pregnant in March 2006 on the first try and had a perfect pregnancy, resulting in our son who is now 3 1/2. We began trying to conceive again in August 2008. We have been through a series of failed IUIs. After taking a break, we became pregnant naturally in March 2010, only to result in a miscarriage at 5 1/2 weeks. We then got pregnant again naturally in May 2010, ending in a miscarriage at 7 weeks. We have been working with the Sher Institute in Bedminster, NJ. We had the immune blood testing done on both my husband and myself, and out of the 3 tests on me, found out that I have elevated natural killer cells (12.3). After reading your blog, I am very unclear as to why I have these elevated NKcells if all of our other blood tests came out normal. From what it sounds like, the NK cells are activated only if the DQalphas are similar, which is not our case. Is it possible to have elevated natural killer cells with nothing else going on? Could I have had these when I got pregnant with my son and, if so, how did I carry that pregancy to term? Thank you for any input you can give us...

We should talk. Call 702-699-7437 to set it up. G...

2010-04-12T16:34:22.035-07:00

We should talk. Call 702-699-7437 to set it up.

Geoff Sher

Thank you so much for your response, I am getting ...

2010-04-10T18:44:13.049-07:00

Thank you so much for your response, I am getting my doctor to contact the lab and try to arrange tests asap.

Since my previous comment we had a fifth miscarriage after IVF, this time even earlier (failure began before four weeks) so the urgency to sort this out is even greater.

I can tell you that it is not available in Austral...

2010-03-08T22:23:35.437-08:00

I can tell you that it is not available in Australia since I see many patients here iun the U.S from your country.

I suggest you have your blood tested for NKa and that your and your husband's blood be matched for both DQ alpha and HLA similarities. The bloods can be sent to Reproductive Immunology Associates (RIA) in the U.S.A. Call them at 818-648-3551 and they will provide details.

Geoff Sher

I am in the difficult situation of recurrent pregn...

2010-02-06T04:50:58.042-08:00

I am in the difficult situation of recurrent pregnancy loss (four miscarriages in one year, all arresting by six weeks, no previous pregnancies/children). We have had many tests, including karotyping, and so far there are no answers.

We are now undergoing IVF to have CGH (four blasts are currently being tested, by array-CGH, for a possible future frozen transfer). But I am worried that even if they find a chromosomally "normal" embryo, if we have an undiagnosed underlying immunological issue we will be wasting our time transferring that embryo.

I haven't yet had a NK cell biopsy but my specialist has mentioned it. However having read your website, you recommend the K-562 test rather than endometrial biopsy. I am in Australia and I realise that testing and research varies by country. Could you please you point me to any more information about this test so I can see if it is available here?