Comments on IVF Authority: Egg Quality and Ovarian Reserve: The Effect of FSH...

Dear Dr Sher, I am 37 and have an AMH of 6.0 and n...

2011-05-30T03:14:01.949-07:00

Dear Dr Sher, I am 37 and have an AMH of 6.0 and normal Day3 FSH, and my response to 450IU of gonal F was good. I had 11 mature eggs retrieved. Quality aside, what sort of group would you put me in? Would I be considered as under diminished ovarian reserve to you?

My FS told me today that he would have me on antagonist (Gonal F and oragultron) next cycle but refused to alter the protocol to bring the antagonist injections closer to gonal F. He mentioned I was still considered within the normal pool of patients.

Dr Dr Sher, thank you so much for your reply. I wi...

2011-05-28T16:08:25.089-07:00

Dr Dr Sher, thank you so much for your reply. I wish I live in USA to visit your clinic! I am in Australia. I am very impressed with your work and SIRM and. Your blog is very informative and educational.

Hi Mum20neds, The high dose of FSH alone should n...

2011-05-26T11:50:10.956-07:00

Hi Mum20neds,

The high dose of FSH alone should not adversely affect egg quality. Rather the woman's age and the protocol used for ovarian stimulation needs to be individualized.

Call 800-780-7437 so we can discuss.

Geoff Sher

Hi Melissa, The answer is complex, Perhaps we sho...

2011-05-26T11:48:16.830-07:00

Hi Melissa,

The answer is complex, Perhaps we should talk. Call800-780-7437 and set up a free phone consultation.

Geoff Sher

Hi Ashermans There is no reliable way to measure ...

2011-05-26T11:47:04.880-07:00

Hi Ashermans

There is no reliable way to measure the effect of LH on ovarian androgen production. Peripheral blood testing is not reliable.

Don't take DHEA, it is converted to Testosterone in the ovary.

Geoff Sher

Dear Dr Sher, can a high dose of FSH (eg 450IU) du...

2011-05-26T04:12:24.464-07:00

Dear Dr Sher, can a high dose of FSH (eg 450IU) during Stim on a long down regulation cycle with only GnRH agonist compromise egg quality?

Does SIRM grade egg quality for eggs retrieved? I failed two cycles and my clinic told me my retrieved eggs were mature (having the polar body) but that was it. I dont even know the quality of them. Mature is such a vague description.

I know maximum E2 level before egg retrieval gives an idea of how many eggs there are in the ovaries but does it indicate egg quality as well? Thanks!

I just went through my 2nd failed IVF and already ...

2011-03-01T06:42:16.220-08:00

I just went through my 2nd failed IVF and already thinking of how to proceed with the 3rd. We started IVF due to male factor issues, but now the doctor is saying that my failed cycles likely point to egg quality issues. He is basing this on the fact that I have needed high does of follistim (up to 600 for 11 days) both cycles, and my E2 levels peaked (day 10/11) just around 1000 both times. However, my day 3 FSH has always been low and age is on my side. So my question is if you agree this is in fact an egg quality issue or just the wrong protocol? Both cycles resulted in 6-8 cell, top grade embryos at day 3 but of the 2 transferred each time, none resulted positively. Your thoughts??

Hi Dr Sher, Thanks for your very informative posts...

2011-02-01T19:14:38.783-08:00

Hi Dr Sher, Thanks for your very informative posts. I was interested to learn that overproduction of testosterone (from high levels of LH) is detrimental to egg quality. How does one know if they are producing too much LH- what are the normal levels and when should they be measured? Also, what are your views on the limited evidence that DHEA may improve egg quality given that some of it is converted into testosterone?
Thank you.